Pancreatic cancer

Most patients have systemic appearance of the disease such as asthenia, anorexia, and weight loss. Other manifestations include deep and superficial venous thrombosis, panniculitis, features of obstructive jaundice, gastric outlet obstruction, increased abdominal girth, and depression. Obstruction of the pancreatic duct may lead to pancreatitis. Patients with pancreatic cancer often have dysglycemia. Indeed, pancreatic cancer should be considered in the differential diagnoses of acute pancreatitis and newly diagnosed diabetes. Physical examination may reveal jaundice, temporal wasting, peripheral lymphadenopathy, hepatomegaly, and ascites